While peopletripping on DMToften drop off all sensing of time , the crest essence of the drug only last for about 10 to 20 moment before subsiding completely in around half an 60 minutes . However , in a yet - to - be - published paper , researchers say they have get by to extend the intense phase of the DMT land to a full 30 minutes , potentially open up up raw opportunity for personalized therapy trips or further inquiry into theouter reaches of human knowingness .

For instance , while exploiter regularly report meet with otherworldly character – or “ entity ” – during their DMT - bring on visionary voyages , scientist are yet to poke into the nervous underpinnings of these leftover fantasm . consort to the study source , though , protract trips “ could be utile in neuroimaging studies with purpose related to awareness inquiry e.g. , investigating the neural correlate of ‘ entity experience ’ or ‘ absorption into alternate realities ’ . "

While DMT can be fume or administered intravenously , both of these method acting loosely give rise to fleeting trips . “ DMT ’s immanent effect start out within seconds , hit their point intensity within two to three moment and subsiding thereafter , with paltry outcome felt after about 30 minutes , ” explicate the researchers .

To increase the length of the experience , the team intravenously administered a “ constant - rate infusion ” to 11 volunteers . Doing so countenance them “ to keep subjects in steady levels of immersion into the DMT experience over an lengthy menstruum of 30 minutes . ”

The drug ’s event then decreased dramatically as soon as the infusion finish and had worn off entirely by about 20 minutes after .

The elemental focal point of the study was to determine the refuge and efficaciousness of this method for supersizingDMTtrips . Ultimately , the authors conclude that their proficiency successfully prolongs the experience “ in a stable and tolerable way , ” with no increases in anxiety or hurtful changes in heart pace .

“ Subjective drug effect appeared within one minute of the commencement of the bolus injection , peak at two transactions , and settled at a slightly lower - than - peak intensity for the duration of the infusion , ” write the researchers .

Interestingly , however , they report that while blood plasma tier of DMT increased throughout the half - hour infusion period , the strength of the stumble faded more or less after about 20 proceedings . The author theorize that this may mull over an step-up in “ permissiveness ” to the drug ’s force after a certain period of time .

Like many other psychedelics , DMT is currently being studied as a possible adjunct to psychotherapy and has shown promise at alleviating certainmental health problems . According to the researchers , the drug ’s brusk half - life stand for that its effects tend to wear off much faster than those of psilocybin , LSD or methylenedioxymethamphetamine , thus get DMT more suitable for certain patients .

Having now highlighted the safety of protracted DMT experience , the subject writer say it may be possible to harness the drug ’s effects for “ precision psychological medicine ” , whereby trip can be manipulated to attain affected role - specific goals .

“ The successful and whippy reference of DMT administration stupefy a pregnant opportunity for the diligence of DMT in clinical and therapeutical configurations , where the distance , strength and dynamics of the psychedelic experience can be adjust concord to the pauperization of the person , ” they write .

The report is currently awaiting peer review but can be viewed as a preprint onPsyArXiv .